Research Strategies for Behavioral Teratology Studies
نویسندگان
چکیده
منابع مشابه
Research strategies for behavioral teratology studies.
Several compelling aruguments have been advanced in support of expanding the use of "behavioral teratology" evaluations as routine components of toxicologic screening procedures. As a basis for development of effective behavioral teratology screening approaches, a conceptual framework is presented which interrelates: (1) changes in relative functional brain capacity with age, (2) possible times...
متن کاملBehavioral teratology: overview.
The field of teratology has expanded in recent years to include the effects of prenatal insult on the function of postnatal animals. This broadening of teratology reflects an awareness of the need to look for more subtle manifestations of developmental toxicity than gross morphologic changes. One aspect of postnatal function which is receiving a great deal of attention is called behavioral tera...
متن کاملA mixed model framework for teratology studies.
A mixed model framework is presented to model the characteristic multivariate binary anomaly data as provided in some teratology studies. The key features of the model are the incorporation of covariate effects, a flexible random effects distribution by means of a finite mixture, and the application of copula functions to better account for the relation structure of the anomalies. The framework...
متن کامل[Present status of behavioral teratology in Japan].
The thalidomide catastrophe in 1959-1962 has given great impetus to the basic research interests in the adverse effects of various insults on germ cells, embryos, fetuses, and immature postnatal individuals. It has called further attention to behavioral ability to learn or respond appropriately to a changing environment in the offspring that are prenatally exposed to various insults, even thoug...
متن کاملBehavioral teratology of mercury and its compounds.
Mercury and its compounds have a wide spectrum of toxicities depending upon the chemical forms and modes of exposure. Among the various chemical forms, mercury vapor and methylmercury are well known and established as neurotoxic agents. Since the disasters in Minamata and Iraq, in which fetuses were more susceptible than adults to methylmercury exposure, much attention has been focused on prena...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1976
ISSN: 0091-6765
DOI: 10.2307/3428688